TPMT Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
TPMT Polyclonal Antibody
Catalog Number
RD252714A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Immunogen Information
Immunogen
Fusion protein of human TPMT
Swissprot
P51580
Synonyms
HGNC:12014S adenosyl L methionine thiopurine S methyltransferaseThiopurine methyltransferaseThiopurine S methyltransferaseThiopurine S-methyltransferaseTPMTTPMT
Gene Accession
BC005339
Applications
Research Areas