RIC8A Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
RIC8A Polyclonal Antibody
Catalog Number
RD252943A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Immunogen Information
Immunogen
Fusion protein of human RIC8A
Swissprot
Q9NPQ8
Synonyms
MGC104517MGC131931MGC148073MGC148074Protein Ric-8Aresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)RIC8RIC8ARIC8ASynembryn-A
Gene Accession
BC011821
Applications
Research Areas