This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.
Immunogen Information
Immunogen
Recombinant protein of human TRIM21
Gene ID
6737
Swissprot
P19474
Synonyms
52 kDa ribonucleoprotein autoantigen Ro/SS-A52 kDa Ro protein52kD Ro/SSA autoantigenAutoantigen Ro/SSA52-KDE3 ubiquitin-protein ligase TRIM21RING finger protein 81RNF81Ro 52Ro(SS-A)Ro52RO52Sicca syndrome antigen ASjoegren syndrome type A anti