Recombinant SF3B1 Monoclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
Recombinant SF3B1 Monoclonal Antibody
Catalog Number
RD86983A
Clonality
Monoclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Background
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
Immunogen Information
Immunogen
A synthetic peptide of human SF3B1
Gene ID
23451
Swissprot
O75533
Synonyms
SF3B1Hsh155MDSPRP10PRPF10SAP155SF3b155
Calculated MW
181kDa
Observed MW
190kDa
Applications
Conjugation
Unconjugated
Dilution
WB 1:500-1:1000, IHC 1:50-1:100
Concentration
300 μg/mL
Storage Buffer
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas