This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Phosphorylates 'Ser-311' of RELA subunit of NF-kappa-B.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.
Immunogen Information
Immunogen
Synthesized peptide derived from human PKC ζ around the non-phosphorylation site of Thr560.
Swissprot
Q05513
Synonyms
14-3-3-zetaisoformAI098070aPKCzetaC80388EC 2.7.11.13KPCZnPKC zetanPKC-zetaOTTHUMP00000001368OTTHUMP00000044160PKC 2PKC ZETAPKC2PkczPKCZETAPKM-zetaincludedPRKCZProtein kinase C zetaProtein kinase C zeta formProtein kinase C zeta typer1