The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Immunogen Information
Immunogen
Synthetic peptide of human PIEZO2
Swissprot
Q9H5I5
Synonyms
Family with sequence similarity 38 member BFLJ23144FLJ23403HsT748Hypothetical protein LOC63895PIEZ2Piezo-type mechanosensitive ion channel component 2Piezo2Protein FAM38B