PERK Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
PERK Polyclonal Antibody
Catalog Number
RD232546A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Background
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
Immunogen Information
Immunogen
Synthesized peptide derived from the N-terminal region of human PERK
Swissprot
Q9NZJ5
Synonyms
DKFZp781H1925E2AK3EC 2.7.11.1Eif2ak3Eukaryotic translation initiation factor 2 alpha kinase 3Eukaryotic translation initiation factor 2-alpha kinase 3Heme regulated EIF2 alpha kinaseHRIHsPEKPancreatic eIF2 alpha kinasePancreatic eIF2-alpha kinas
Calculated MW
125 kDa
Observed MW
125 kDa
Applications
Reactivity
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:40000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol pH 7.4.
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas