PE/Cyanine5 Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
PE/Cyanine5 Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
Catalog Number
RD30834F
Clonality
Monoclonal
Isotype
Rat IgG2a, κ
Host
Background
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.
Immunogen Information
Gene ID
20371
Synonyms
Forkhead box protein P3ScurfinJM2IPEXZinc finger protein JM2
Applications
Tested Applications
Conjugation
PE/Cyanine5
Concentration
0.2 mg/mL
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage Instructions
This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.