CD226 (DNAM-1) is constitutively expressed on native CD8+ cells and on CD4+ T cells, macrophages and NK cells.This antibody (10E5) was reported to bind about 40% of inactivated CD4+ cells and binds only to differentiated Th1 cells, but not to Th2 or Th0 cells.It is also reported to suppress antigen-specific T cell expansion and EAE (experimental allergic encephalitis) mediated by Th1 cells.
Immunogen Information
Gene ID
225825
Synonyms
DNAM-1PTA1 (platelet and T cell activation antigen 1)TLISA1LFA-1 associated Molecule PTA-1