MAFA Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
MAFA Polyclonal Antibody
Catalog Number
RD253394A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Background
Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity.
Immunogen Information
Immunogen
Synthetic peptide of human MAFA
Swissprot
Q8NHW3
Synonyms
HMafAMafaMAFAPancreatic beta cell specific transcriptional activatorPancreatic beta-cell-specific transcriptional activatorRIPE3b1Transcription factor MafATranscription factor RIPE3b1v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Calculated MW
37 kDa
Observed MW
Refer to figures
Gene Accession
NP963883
Applications
Research Areas