HUWE1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
HUWE1 Polyclonal Antibody
Catalog Number
RD219540A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Background
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.
Immunogen Information
Immunogen
Synthetic peptide of human HUWE1
Swissprot
Q7Z6Z7
Synonyms
ARF binding protein 1ARF BP1ARF-binding protein 1ARF-BP1BJ-HCC-24 tumor antigenE3 ubiquitin protein ligase HUWE1E3 ubiquitin-protein ligase HUWE1HECTHECT domain protein LASU1HECT UBA and WWE domain containing protein 1HectH9Homologous to E6AP c
Gene Accession
NP113584
Applications
Research Areas