HSPA5 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Product Name
HSPA5 Polyclonal Antibody
Catalog Number
RD90660A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Background
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen.Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate .Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR).In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1.
Immunogen Information
Immunogen
Recombinant Human HSPA5 protein expressed by E.coli
Swissprot
P11021
Synonyms
HSPA5GRP7878 kDa glucose-regulated proteinBinding-immunoglobulin proteinHeat shock protein 70 family protein 5Heat shock protein family A member 5Immunoglobulin heavy chain-binding protein
Calculated MW
25 kDa
Observed MW
27 kDa
Applications
Research Areas