This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Immunogen Information
Immunogen
Recombinant fusion protein of human FUS
Gene ID
2521
Swissprot
P35637
Synonyms
FUSALS6ETM4FUS1HNRNPP2POMP75TLSRNA-binding protein FUS