Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles.
Immunogen Information
Immunogen
Recombinant protein corresponding to Mouse NOX2
Swissprot
Q61093
Synonyms
AMCBX2CGDCGD91-phoxCY24BCYBBCytochrome b 245beta polypeptideCytochrome b(558) beta chainCytochrome b(558) subunit betaCytochrome b-245 heavy chainCytochrome b558 subunit betaGP91 PHOXgp91-1gp91-phoxGP91PHOXHeme-binding membrane glycoprotein