This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
Immunogen Information
Immunogen
Synthesized peptide derived from human CREB-1 around the non-phosphorylation site of Ser133.
Swissprot
P16220
Synonyms
Active transcription factor CREBcAMP response element binding protein 1cAMP response element binding proteincAMP responsive element binding protein 1cAMP-responsive element-binding protein 1CREBCREB-1CREB1CREB1Cyclic AMP-responsive element-bindin