Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse ADAM10
Swissprot
O14672,O35598,Q10743
Synonyms
A disintegrin and metalloprotease domain 10A disintegrin and metalloproteinase domain 10AD 10AD10AD18ADA10ADAM 10ADAM metallopeptidase domain 10ADAM10CD 156cCD156cCD156c antigenCDw156disintegrin and metalloproteinase domain containing protein